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1000 Titel
  • AP180 and CALM: Dedicated endocytic adaptors for the retrieval of synaptobrevin 2 at synapses
1000 Autor/in
  1. Koo, Seong Joo |
  2. Puchkov, Dmytro |
  3. Haucke, Volker |
1000 Erscheinungsjahr 2011
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2011-07-01
1000 Erschienen in
1000 Quellenangabe
  • 1(4): 168-172
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2011
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.4161/cl.1.4.18897 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265930/ |
1000 Ergänzendes Material
  • http://www.tandfonline.com/doi/figure/10.4161/cl.1.4.18897?scroll=top&needAccess=true |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Communication between neurons largely occurs at chemical synapses involving conversion of electric to chemical signals. Chemical neurotransmission involves the action potential-driven release of neurotransmitters from synaptic vesicles (SVs) at presynaptic nerve terminals. Fusion of SVs is driven by SNARE complex formation comprising synaptobrevin 2 on the SV membrane and syntaxin 1A and SNAP-25 on the plasma membrane. In order to maintain neurotransmission during repetitive stimulation and to prevent expansion of the presynaptic plasma membrane, exocytic SV fusion needs to be balanced by compensatory retrieval of SV components to regenerate functional vesicles. Our recent work has unraveled a mechanism by which the R-SNARE synaptobrevin 2, the most abundant SV protein and an essential player for exocytic fusion is recycled from the presynaptic membrane. The SNARE motif of synaptobrevin 2 is directly recognized by the ANTH domains of AP180 and CALM, monomeric endocytic adaptors for clathrin-mediated endocytosis. Given that key residues involved in synaptobrevin 2-ANTH domain complex formation are also essential for SNARE assembly, we propose that disassembly of SNARE complexes is a prerequisite for synaptobrevin 2 retrieval, thereby preventing endocytic mis-sorting of the plasma membrane Q-SNAREs syntaxin 1A and SNAP-25. It is tempting to speculate that perturbed synaptobrevin 2 recycling caused by reduction of CALM or AP180 levels may lead to disease as suggested by the genetic association of ANTH domain proteins with neurodegenerative disorders.
1000 Sacherschließung
lokal neurodegenerative disease
lokal AP180
lokal CALM
lokal ANTH domain
lokal SNARE
lokal clathrin-mediated endocytosis
lokal synaptobrevin 2
lokal synapse
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S29vLCAgU2VvbmcgSm9vIA==|http://orcid.org/0000-0001-8341-4847|http://orcid.org/0000-0003-3119-6993
1000 Label
1000 Förderer
  1. DFG |
  2. European Science Foundation |
1000 Fördernummer
  1. SFB958/A1; HA2686/6-1
  2. -
1000 Förderprogramm
  1. -
  2. ESF-EUROMEMBRANE
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer DFG |
    1000 Förderprogramm -
    1000 Fördernummer SFB958/A1; HA2686/6-1
  2. 1000 joinedFunding-child
    1000 Förderer European Science Foundation |
    1000 Förderprogramm ESF-EUROMEMBRANE
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403241.rdf
1000 Erstellt am 2017-06-27T12:02:35.781+0200
1000 Erstellt von 21
1000 beschreibt frl:6403241
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet 2022-08-18T07:57:30.017+0200
1000 Objekt bearb. Thu Mar 04 08:19:56 CET 2021
1000 Vgl. frl:6403241
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403241 |
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