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1000 Titel
  • Genome-wide association analysis and functional annotation of positional candidate genes for feed conversion efficiency and growth rate in pigs
1000 Autor/in
  1. Horodyska, Justyna |
  2. Hamill, Ruth M. |
  3. Varley, Patrick F. |
  4. Reyer, Henry |
  5. Wimmers, Klaus |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-06-12
1000 Erschienen in
1000 Quellenangabe
  • 12(6): e0173482
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0173482 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467825/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173482#sec014 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Feed conversion efficiency is a measure of how well an animal converts feed into live weight and it is typically expressed as feed conversion ratio (FCR). FCR and related traits like growth rate (e.g. days to 110 kg—D110) are of high interest for animal breeders, farmers and society due to implications on animal performance, feeding costs and environmental sustainability. The objective of this study was to identify genomic regions associated with FCR and D110 in pigs. A total of 952 terminal line boars, showing an individual variation in FCR, were genotyped using 60K SNP-Chips. Markers were tested for associations with estimated breeding values (EBV) for FCR and D110. For FCR, the largest number of associated SNPs was located on chromosomes 4 (30 SNPs), 1 (25 SNPs), X (15 SNPs) and 6 (12 SNPs). The most prominent genomic regions for D110 were identified on chromosomes 15 (10 SNPs), 1 and 4 (both 9 SNPs). The most significantly associated SNPs for FCR and D110 mapped 129.8 Kb from METTL11B (chromosome 4) and 32Kb from MBD5 (chromosome 15), respectively. A list of positional genes, closest to significantly associated SNPs, was used to identify enriched pathways and biological functions related to the QTL for both traits. A number of candidate genes were significantly overrepresented in pathways of immune cell trafficking, lymphoid tissue structure, organ morphology, endocrine system function, lipid metabolism, and energy production. After resequencing the coding region of selected positional and functional candidate genes, six SNPs were genotyped in a subset of boars. SNPs in PRKDC, SELL, NR2E1 and AKRIC3 showed significant associations with EBVs for FCR/D110. The study revealed a number of chromosomal regions and candidate genes affecting FCR/D110 and pointed to corresponding biological pathways related to lipid metabolism, olfactory reception, and also immunological status.
1000 Sacherschließung
lokal Genotyping
lokal Lipid metabolism
lokal Phenotypes
lokal Genome-wide association studies
lokal Genomic databases
lokal Swine
lokal Polymerase chain reaction
lokal Quantitative trait loci
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SG9yb2R5c2thLCBKdXN0eW5h|https://frl.publisso.de/adhoc/creator/SGFtaWxsLCBSdXRoIE0u|https://frl.publisso.de/adhoc/creator/VmFybGV5LCBQYXRyaWNrIEYu|http://orcid.org/0000-0001-6470-0434|http://orcid.org/0000-0002-9523-6790
1000 Label
1000 Förderer
  1. European Union |
  2. Hermitage Genetics |
1000 Fördernummer
  1. 311794
  2. -
1000 Förderprogramm
  1. Seventh Framework Programme for research, technological development and demonstration; ECO-FCE
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm Seventh Framework Programme for research, technological development and demonstration; ECO-FCE
    1000 Fördernummer 311794
  2. 1000 joinedFunding-child
    1000 Förderer Hermitage Genetics |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403511.rdf
1000 Erstellt am 2017-07-18T11:28:01.767+0200
1000 Erstellt von 25
1000 beschreibt frl:6403511
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Wed Mar 31 08:53:11 CEST 2021
1000 Objekt bearb. Wed Mar 31 08:53:10 CEST 2021
1000 Vgl. frl:6403511
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403511 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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