Stensrud-et-al_2021_A generalized theory of separable effects.pdf 945,88KB
1000 Titel
  • A generalized theory of separable effects in competing event settings
1000 Autor/in
  1. Stensrud, Mats Julius |
  2. Hernán, Miguel A. |
  3. Tchetgen Tchetgen, Eric |
  4. Robins, James M. |
  5. Didelez, Vanessa |
  6. Young, Jessica G. |
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-09-01
1000 Erschienen in
1000 Quellenangabe
  • 27(4):588-631
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • |
  • |
1000 Ergänzendes Material
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • In competing event settings, a counterfactual contrast of cause-specific cumulative incidences quantifies the total causal effect of a treatment on the event of interest. However, effects of treatment on the competing event may indirectly contribute to this total effect, complicating its interpretation. We previously proposed the separable effects to define direct and indirect effects of the treatment on the event of interest. This definition was given in a simple setting, where the treatment was decomposed into two components acting along two separate causal pathways. Here we generalize the notion of separable effects, allowing for interpretation, identification and estimation in a wide variety of settings. We propose and discuss a definition of separable effects that is applicable to general time-varying structures, where the separable effects can still be meaningfully interpreted as effects of modified treatments, even when they cannot be regarded as direct and indirect effects. For these settings we derive weaker conditions for identification of separable effects in studies where decomposed, or otherwise modified, treatments are not yet available; in particular, these conditions allow for time-varying common causes of the event of interest, the competing events and loss to follow-up. We also propose semi-parametric weighted estimators that are straightforward to implement. We stress that unlike previous definitions of direct and indirect effects, the separable effects can be subject to empirical scrutiny in future studies.
1000 Sacherschließung
lokal Causal inference
lokal Effect decomposition
lokal G-formula
lokal Hazard functions
lokal Competing events
lokal Separable effects
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Label
1000 Förderer
  1. École Polytechnique Fédérale de Lausanne |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. Open Access funding
1000 Dateien
  1. A generalized theory of separable effects in competing event settings
1000 Förderung
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    1000 Förderer École Polytechnique Fédérale de Lausanne |
    1000 Förderprogramm Open Access funding
    1000 Fördernummer -
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