The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients

  1. Marklein, Bianka
  2. Jenning, Madeleine
  3. Konthur, Zoltán
  4. Häupl, Thomas
  5. Welzel, Franziska
  6. Nonhoff, Ute
  7. Krobitsch, Sylvia
  8. Mulder, Debbie M.
  9. Koenders, Marije I.
  10. Joshua, Vijay
  11. Cope, Andrew P.
  12. Shlomchik, Mark J.
  13. Anders, Hans-Joachim
  14. Burmester, Gerd R.
  15. Hensvold, Aase
  16. Catrina, Anca I.
  17. Rönnelid, Johan
  18. Steiner, Günter
  19. Skriner, Karl ORCID logo

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1000 Titel
  • The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients
1000 Autor/in
  1. Marklein, Bianka |
  2. Jenning, Madeleine |
  3. Konthur, Zoltán |
  4. Häupl, Thomas |
  5. Welzel, Franziska |
  6. Nonhoff, Ute |
  7. Krobitsch, Sylvia |
  8. Mulder, Debbie M. |
  9. Koenders, Marije I. |
  10. Joshua, Vijay |
  11. Cope, Andrew P. |
  12. Shlomchik, Mark J. |
  13. Anders, Hans-Joachim |
  14. Burmester, Gerd R. |
  15. Hensvold, Aase |
  16. Catrina, Anca I. |
  17. Rönnelid, Johan |
  18. Steiner, Günter |
  19. Skriner, Karl |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-09-14
1000 Erschienen in
1000 Quellenangabe
  • 23(1):239
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13075-021-02603-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439038/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!There is a need for biomarker to identify patients 'at risk' for rheumatoid arthritis (risk-RA) and to better predict the therapeutic response and in this study we tested the hypothesis that novel native and citrullinated heterogeneous nuclear ribonucleoprotein (hnRNP)-DL autoantibodies could be possible biomarkers.!##!Methods!#!Using protein macroarray and ELISA, epitope recognition against hnRNP-DL was analysed in sera from different developed RA disease and diagnosed SLE patients. Toll-like receptor (TLR) 7/9 and myeloid differentiation primary response gene 88 (MyD88)-dependency were studied in sera from murine disease models. HnRNP-DL expression in cultivated cells and synovial tissue was analysed by indirect immunofluorescence, immunoblot and immunohistochemistry.!##!Results!#!HnRNP-DL was highly expressed in stress granules, citrullinated in the rheumatoid joint and targeted by autoantibodies either as native or citrullinated proteins in patient subsets with different developed RA disease. Structural citrullination dependent epitopes (SCEs) of hnRNP-DL were detected in 58% of the SLE patients although 98% of these sera were α-CCP-2-negative. To obtain a specific citrullinated signal value, we subtracted the native antibody value from the citrullinated signal. The citrullinated/native index of autoantibodies against hnRNP-DL (CN!##!Conclusion!#!CN
1000 Sacherschließung
lokal Citrullination [MeSH]
lokal Anti-CCP
lokal Humans [MeSH]
lokal Rheumatoid arthritis
lokal Arthritis, Rheumatoid/drug therapy [MeSH]
lokal Peptides, Cyclic [MeSH]
lokal Systemic lupus erythematosus
lokal Animals [MeSH]
lokal Mice [MeSH]
lokal ACPA
lokal Epitopes [MeSH]
lokal Heterogeneous-Nuclear Ribonucleoproteins [MeSH]
lokal Autoantibodies [MeSH]
lokal Autoantigens
lokal Shared epitope
lokal Treatment
lokal Research Article
lokal Rheumatoid factor
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TWFya2xlaW4sIEJpYW5rYQ==|https://frl.publisso.de/adhoc/uri/SmVubmluZywgTWFkZWxlaW5l|https://frl.publisso.de/adhoc/uri/S29udGh1ciwgWm9sdMOhbg==|https://frl.publisso.de/adhoc/uri/SMOkdXBsLCBUaG9tYXM=|https://frl.publisso.de/adhoc/uri/V2VsemVsLCBGcmFuemlza2E=|https://frl.publisso.de/adhoc/uri/Tm9uaG9mZiwgVXRl|https://frl.publisso.de/adhoc/uri/S3JvYml0c2NoLCBTeWx2aWE=|https://frl.publisso.de/adhoc/uri/TXVsZGVyLCBEZWJiaWUgTS4=|https://frl.publisso.de/adhoc/uri/S29lbmRlcnMsIE1hcmlqZSBJLg==|https://frl.publisso.de/adhoc/uri/Sm9zaHVhLCBWaWpheQ==|https://frl.publisso.de/adhoc/uri/Q29wZSwgQW5kcmV3IFAu|https://frl.publisso.de/adhoc/uri/U2hsb21jaGlrLCBNYXJrIEou|https://frl.publisso.de/adhoc/uri/QW5kZXJzLCBIYW5zLUpvYWNoaW0=|https://frl.publisso.de/adhoc/uri/QnVybWVzdGVyLCBHZXJkIFIu|https://frl.publisso.de/adhoc/uri/SGVuc3ZvbGQsIEFhc2U=|https://frl.publisso.de/adhoc/uri/Q2F0cmluYSwgQW5jYSBJLg==|https://frl.publisso.de/adhoc/uri/UsO2bm5lbGlkLCBKb2hhbg==|https://frl.publisso.de/adhoc/uri/U3RlaW5lciwgR8O8bnRlcg==|https://orcid.org/0000-0002-5415-270X
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