Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study

  1. Kochlik, Bastian ORCID logo
  2. Herpich, Catrin ORCID logo
  3. Moreno‐Villanueva, Maria
  4. Klaus, Susanne ORCID logo
  5. Müller-Werdan, Ursula ORCID logo
  6. Weinberger, Birgit ORCID logo
  7. Fiegl, Simone
  8. Toussaint, Olivier
  9. Debacq-Chainiaux, Florence ORCID logo
  10. Schön, Christiane ORCID logo
  11. Bernhard, Jürgen
  12. Breusing, Nicolle
  13. Gonos, Efstathios S.
  14. Franceschi, Claudio ORCID logo
  15. Capri, Miriam ORCID logo
  16. Sikora, Ewa ORCID logo
  17. Hervonen, Antti
  18. Hurme, Mikko ORCID logo
  19. Slagboom, Pieternella ORCID logo
  20. Dollé, Martijn ORCID logo
  21. Jansen, Eugene ORCID logo
  22. Grune, Tilman ORCID logo
  23. Bürkle, Alexander ORCID logo
  24. Norman, Kristina ORCID logo

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1000 Titel
  • Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study
1000 Autor/in
  1. Kochlik, Bastian |
  2. Herpich, Catrin |
  3. Moreno‐Villanueva, Maria |
  4. Klaus, Susanne |
  5. Müller-Werdan, Ursula |
  6. Weinberger, Birgit |
  7. Fiegl, Simone |
  8. Toussaint, Olivier |
  9. Debacq-Chainiaux, Florence |
  10. Schön, Christiane |
  11. Bernhard, Jürgen |
  12. Breusing, Nicolle |
  13. Gonos, Efstathios S. |
  14. Franceschi, Claudio |
  15. Capri, Miriam |
  16. Sikora, Ewa |
  17. Hervonen, Antti |
  18. Hurme, Mikko |
  19. Slagboom, Pieternella |
  20. Dollé, Martijn |
  21. Jansen, Eugene |
  22. Grune, Tilman |
  23. Bürkle, Alexander |
  24. Norman, Kristina |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-09-16
1000 Erschienen in
1000 Quellenangabe
  • 46(2):1657-1669
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11357-023-00902-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828354/ |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007/s11357-023-00902-6#Sec12 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study. In the present work, samples and data of MARK-AGE (“European study to establish bioMARKers of human AGEing“) participants (N = 2736) were analyzed. Cognitive frailty was determined by the global cognitive functioning score (GCF) and depression by the Self-Rating Depression Scale (SDS score). Adults were classified into three groups: (I) neither-cognitive-frailty-nor-depression, (II) either-cognitive-frailty-or-depression or (III) both-cognitive-frailty-and-depression. Cross-sectional associations were determined by unadjusted and by age, BMI, sex, comorbidities and hsCRP-adjusted linear and logistic regression analyses. Cognitive frailty, depression, age and GDF15 were significantly related within the whole study sample. High GDF15 levels were significantly associated with both-cognitive-frailty-and-depression (adjusted β = 0.177 [0.044 – 0.310], p = 0.009), and with low GCF scores and high SDS scores. High GDF15 concentrations and quartiles were significantly associated with higher odds to have both-cognitive-frailty-and-depression (adjusted odds ratio = 2.353 [1.267 – 4.372], p = 0.007; and adjusted odds ratio = 1.414 [1.025 – 1.951], p = 0.035, respectively) independent of age, BMI, sex, comorbidities and hsCRP. These associations remained significant when evaluating older adults. We conclude that plasma GDF15 concentrations are significantly associated with combined cognitive-frailty-and-depression status and, with cognitive frailty and depressive symptoms separately in old as well as young community-dwelling adults.
1000 Sacherschließung
lokal Aging
lokal GDF15
lokal Depression
lokal Cognitive frailty
lokal Biomarker
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0003-0214-7092|http://orcid.org/0000-0003-3059-1705|https://frl.publisso.de/adhoc/uri/TW9yZW5v4oCRVmlsbGFudWV2YSwgTWFyaWE=|http://orcid.org/0000-0001-8726-185X|http://orcid.org/0000-0003-4440-8991|http://orcid.org/0000-0002-7084-946X|https://frl.publisso.de/adhoc/uri/RmllZ2wsIFNpbW9uZQ==|https://frl.publisso.de/adhoc/uri/VG91c3NhaW50LCBPbGl2aWVy|http://orcid.org/0000-0003-3949-395X|http://orcid.org/0000-0003-3787-5268|https://frl.publisso.de/adhoc/uri/QmVybmhhcmQsIErDvHJnZW4=|https://frl.publisso.de/adhoc/uri/QnJldXNpbmcsIE5pY29sbGU=|https://frl.publisso.de/adhoc/uri/R29ub3MsIEVmc3RhdGhpb3MgUy4=|http://orcid.org/0000-0001-9841-6386|http://orcid.org/0000-0001-9077-0401|http://orcid.org/0000-0002-1111-1748|https://frl.publisso.de/adhoc/uri/SGVydm9uZW4sIEFudHRp|http://orcid.org/0000-0002-8614-1044|http://orcid.org/0000-0002-2875-4723|http://orcid.org/0000-0001-6137-6544|http://orcid.org/0000-0002-3151-5897|http://orcid.org/0000-0003-4775-9973|http://orcid.org/0000-0003-1069-2656|http://orcid.org/0000-0003-2029-9102
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