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ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress

2022 . WU, Xingxuan | Xu, Shibin | Wang, Peipei | wang, zhao-qi | Chen, Hongxiang | Xu, Xingzhi | PENG, BIN

Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response

2021 . Roßmann, Laura | Bagola, Katrin | Stephen, Tharshana | Gerards, Anna Lisa | Walber, Bianca | Ullrich, Anja | Schülke, Stefan | Kamp, Christel | Spreitzer, Ingo | Hasan, Milena | David-Watine, Brigitte | Shorte, Spencer | Bastian, Max | van Zandbergen, Ger

Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction

2019 . Rodriguez-Fernandez, Imilce A. | Qi, Yanyan | Jasper, Heinrich

BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells

The age-regulated zinc finger factor ZNF367 is a new modulator of neuroblast proliferation during embryonic neurogenesis

2018 . Naef, Valentina | Monticelli, Sara | Corsinovi, Debora | Mazzetto, Maria T. | Cellerino, Alessandro | Ori, Michela

TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress

2016 . Pai, Govind M. | Zielinski, Alexandra | Koalick, Dennis | Ludwig, Kristin | wang, zhao-qi | Borgmann, Kerstin | Pospiech, Helmut | Rubio, Ignacio

Xpg limits the expansion of haematopoietic stem and progenitor cells after ionising radiation

2016 . Avila, Alush I. | Illing, Anett | Becker, Friedrich | Maerz, Lars D. | Morita, Yohei | Philipp, Melanie | Burkhalter, Martin D.

The tumour suppressor CYLD regulates the p53 DNA damage response

2016 . Fernandez-Majada, Vanesa | Welz, Patrick-Simon | Ermolaeva, Maria | Schell, Michael | Adam, Alexander | Dietlein, Felix | Komander, David | Büttner, Reinhard | Thomas, Roman K. | Schumacher, Björn | Pasparakis, manolis

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage

2015 . Tao, Si | Tang, Duozhuang | Morita, Yohei | Sperka, Tobias | Omrani, Omid | Lechel, André | Sakk, Vadim | Kraus, Johann | Kestler, Hans A. | Kühl, Michael | Rudolph, Karl Lenhard

Genome instability of ageing stem cells—Induction and defence mechanisms

2015 . Burkhalter, Martin D. | Rudolph, K. Lenhard | Sperka, Tobias